Inflammatory cell activation in sepsis

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Inflammatory cell activation in sepsis.

The body relies for protection on an effective inflammatory response. To sustain an armoury of inflammatory cells in a state of permanent activation would be impossible and a system whereby such cells can be rapidly activated is, therefore, employed. Upon transition from the resting to activated state inflammatory cells perform multiple defensive functions and are then removed, limiting the dur...

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Association of inflammatory and endothelial cell activation biomarkers with acute kidney injury after sepsis

OBJECTIVE Acute kidney injury (AKI) is a sequela of sepsis associated with increased morbidity and mortality. We sought to determine if individuals with elevated baseline levels of inflammation and endothelial cell activation are at increased risk for future AKI after sepsis. METHODS We conducted an analysis of individuals developing sepsis in the national 30,239 subject REGARDS cohort. Bioma...

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Coagulation activation in sepsis

Sepsis is defined as a systemic inflammatory response syndrome occurring during infection (1). Activation of blood coagulation is a common observation in patients with sepsis (2, 3). Nearly all patients with severe sepsis according to the American College of Chest Physicians (ACCP) criteria (1) display elevated levels of activation products of blood coagulation (4). Since in most cases, no sing...

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Prognostic Validity of Red Cell Distribution Width in Neonatal Sepsis

Background Neonatal sepsis is one of the most critical illness in neonates that is responsible for a great proportion of morbidity and mortality in neonates so early diagnosis and identification of high risk cases is a challenging aim of our study. The purpose of this study was to investigate the prognostic value of red cell distribution width (RDW), in neonatal sepsis at the time of admission ...

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Neonatal Sepsis and Inflammatory Mediators

Neonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult. The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics. Sepsis is the result of an infection associated with a systemic inflammatory response with produc...

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ژورنال

عنوان ژورنال: British Medical Bulletin

سال: 1999

ISSN: 0007-1420,1471-8391

DOI: 10.1258/0007142991902277